VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE
AVIPTADIL
CAS: 40077-57-4
Molecular Formula: C147H238N44O42S
VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE - Names and Identifiers
| Name | AVIPTADIL |
| Synonyms | AVIPTADIL Aviptadil Acetate VASOACTIVE INTESTINAL PEPTIDE VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE (HUMAN, PORCINE) VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, AND RAT VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE VASOACTIVE INTESTINAL PEPTIDE (HUMAN, BOVINE, PORCINE, RAT) VASOACTIVE INTESTINAL PEPTIDE (HUMAN, PORCINE) (BOVINE, RAT, CANINE) |
| CAS | 40077-57-4 |
| InChI | InChI=1/C147H237N43O43S/c1-18-75(12)115(142(229)180-96(56-72(6)7)131(218)183-104(145(232)233)63-110(155)200)188-139(226)106(68-192)185-134(221)101(62-109(154)199)177-130(217)95(55-71(4)5)174-132(219)97(58-81-37-41-84(195)42-38-81)175-125(212)88(33-23-26-49-149)167-123(210)89(34-24-27-50-150)171-140(227)113(73(8)9)186-118(205)76(13)164-121(208)93(47-53-234-17)170-127(214)92(45-46-107(152)197)169-122(209)87(32-22-25-48-148)166-124(211)90(35-28-51-161-146(156)157)168-129(216)94(54-70(2)3)173-126(213)91(36-29-52-162-147(158)159)172-143(230)116(78(15)193)189-136(223)98(59-82-39-43-85(196)44-40-82)176-133(220)100(61-108(153)198)178-135(222)103(65-112(203)204)182-144(231)117(79(16)194)190-137(224)99(57-80-30-20-19-21-31-80)181-141(228)114(74(10)11)187-119(206)77(14)165-128(215)102(64-111(201)202)179-138(225)105(67-191)184-120(207)86(151)60-83-66-160-69-163-83/h19-21,30-31,37-44,66,69-79,86-106,113-117,191-196H,18,22-29,32-36,45-65,67-68,148-151H2,1-17H3,(H2,152,197)(H2,153,198)(H2,154,199)(H2,155,200)(H,160,163)(H,164,208)(H,165,215)(H,166,211)(H,167,210)(H,168,216)(H,169,209)(H,170,214)(H,171,227)(H,172,230)(H,173,213)(H,174,219)(H,175,212)(H,176,220)(H,177,217)(H,178,222)(H,179,225)(H,180,229)(H,181,228)(H,182,231)(H,183,218)(H,184,207)(H,185,221)(H,186,205)(H,187,206)(H,188,226)(H,189,223)(H,190,224)(H,201,202)(H,203,204)(H,232,233)(H4,156,157,161)(H4,158,159,162)/t75-,76-,77-,78+,79+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-,117-/m0/s1 |
| InChIKey | HEOYHMUESMJFDC-RIWXPGAOSA-N |
VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE - Physico-chemical Properties
| Molecular Formula | C147H238N44O42S |
| Molar Mass | 3325.8 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Solubility | 1% acetic acid: soluble 0.1%, clear, colorless |
| Appearance | powder |
| Storage Condition | −20°C |
| MDL | MFCD00167535 |
| In vitro study | Aviptadil inhibits the basal proliferation of pulmonary arterial smooth muscle cells (PASMC) and the mobilization of intracellular free calcium concentration in these cells in a dose-dependent manner.Aviptadil (1 nM-10 μM) produces a concentration-dependent inhibition of CSE-induced cell death in L2 cells. At 10 μM, Aviptadil reduces CSE-stimulated MMP activity and caspase-3 activation in L2 cells.Aviptadil (10 nM-100 μM) attenuates lipopolisaccharide (LPS)-induced MMP-9 activity and its expression by alveolar macrophages (AM) in rats. |
| In vivo study | Aviptadil (1, 3 and 10 mg/kg; intravenous bolus injection) is injected into a tail vein. No-effect dose level is 1 mg/kg. Dose level with first intolerance reactions 3 mg/kg, Lowest lethal dose level is >10 mg/kg. i.v. LD 50 of Aviptadil is >10 mg/kg in males, females and male and female combined after 24 hours and 14 days.Aviptadil (intravenous bolus injection) at 3 mg causes slightly reduced motility, slight ataxia and slight dyspnoea in all 5 male and 5 female animals 15 to 30 minutes after administration. At 10 mg, Aviptadil reveals slightly reduced motility, slight ataxia, and slight dyspnoea 15 to 60 minutes and slightly reduces muscle tone 15 to 30 minutes after administration, respectively, in all male and female animals.Nose-only inhalation exposure of CD1 mice to aerosolized.Aviptadil at a dose of 1546 µg/kg/day is well tolerated and produces no apparent changes in any of the parameters evaluated. No changes are observed after a single dose administration as high as 3920 µg/kg/day. The no-observable-adverse-effect level (NOAEL) is considered to be at least 3920 µg/kg/day fore an acute exposure and 1546 µg/kg/day for a 10 day repeated exposure. |
VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE - Risk and Safety
| WGK Germany | 3 |
VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE - Reference
| Reference Show more | 1. Wang Tingting, Zhang Weiping, Shen Guoming, Wu Song, Cheng Ling, Huang Jinling, Lu Tingting, Chen Chen, Lu Danli. Effects of Huangqi Jianzhong decoction on Leptin-NPY/VIP/GAS signal transduction pathway, thymus index and spleen index in rats with spleen-qi deficiency syndrome [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2015,17(12):31-35. |
VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE - Nature
Open Data Verified Data
- This product is twenty-eight peptide, belonging to the Secretin family. The structure is similar to that of incretin and glucagon. It is widely distributed in the body, and VIP is distributed in most systems and organs, even in neutrophils and mast cells. VIP immunoreactive is present throughout the gastrointestinal tract from the salivary glands of the oral cavity to the rectum. The highest content in the duodenum, followed by the ileum. Its basic concentration in the circulating blood is very low, half-life (0. 85±0.12) min, liver, kidney, brain are cleared it.
- the effect of VIP on the digestive system is to inhibit the contraction of lower esophageal sphincter, stomach, small intestinal circular muscle, gallbladder and anal sphincter of large intestine; Promote the secretion of water and electrolyte in intestinal mucosa; stimulate the secretion of water and electrolytes in the external part of the pancreas, bile and small intestine; Inhibit gastric secretion of gastric acid, water and electrolytes; Stimulate gastrointestinal endocrine cells to secrete insulin, glucagon, somatostatin and pancreatic polypeptide, excitatory enteric neurons. On the circulation and respiratory system, VIP has a moderate positive inotropic effect on the myocardium, increasing cardiac output; Has a diastolic effect on most vascular beds, can reduce diastolic blood pressure and mean arterial pressure, dilates the smooth muscles of the trachea and bronchi and increases ventilation; The effect on neuroendocrine is to stimulate the pituitary to release prolactin, growth hormone, ACTH and LH, and to stimulate the release of renin from the Pararenal cells.
Last Update：2024-01-02 23:10:35
VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.301 ml | 1.503 ml | 3.007 ml |
| 5 mM | 0.06 ml | 0.301 ml | 0.601 ml |
| 10 mM | 0.03 ml | 0.15 ml | 0.301 ml |
| 5 mM | 0.006 ml | 0.03 ml | 0.06 ml |
Last Update：2024-01-02 23:10:35
VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE - Use
Open Data Verified Data
The determination of plasma VIP concentration can be used as a diagnostic measure of VIP tumor, and can also be used as an indicator of treatment or tumor proliferation.
Last Update：2022-01-01 11:11:48
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